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Chia-Che Chang Selected Research

Prodigiosin

12/2012Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines.
8/2012Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells.
7/2012Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
11/2011Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia.
3/2009Prodigiosin down-regulates survivin to facilitate paclitaxel sensitization in human breast carcinoma cell lines.

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Chia-Che Chang Research Topics

Disease

12Neoplasms (Cancer)
11/2021 - 08/2010
5Breast Neoplasms (Breast Cancer)
02/2013 - 12/2007
3Colorectal Neoplasms (Colorectal Cancer)
11/2020 - 12/2016
3Skin Neoplasms (Skin Cancer)
02/2013 - 03/2012
2Brain Injuries (Brain Injury)
12/2021 - 11/2011
2Brain Ischemia (Cerebral Ischemia)
12/2021 - 01/2006
2Infarction (Infarctions)
12/2021 - 01/2006
2Brain Infarction
12/2021 - 11/2011
2B-Cell Lymphoma (Lymphoma, B Cell)
11/2020 - 12/2016
2Inflammation (Inflammations)
12/2018 - 08/2006
2Hypoxia (Hypoxemia)
12/2018 - 11/2011
2Ataxia Telangiectasia (Louis Bar Syndrome)
11/2018 - 02/2013
2Carcinogenesis
12/2016 - 08/2006
2Melanoma (Melanoma, Malignant)
12/2016 - 02/2011
2Basal Cell Carcinoma (Rodent Ulcer)
02/2013 - 03/2012
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2013 - 05/2008
2Neoplasm Metastasis (Metastasis)
10/2012 - 02/2011
1Macular Degeneration (Age-Related Maculopathy)
01/2022
1Stroke (Strokes)
12/2021
1Triple Negative Breast Neoplasms
11/2021
1Glaucoma
01/2021
1Bacterial Infections (Bacterial Infection)
01/2020
1Obesity
08/2019
1Liver Cirrhosis (Hepatic Cirrhosis)
08/2019
1Multiple Myeloma
07/2019
1Glioblastoma (Glioblastoma Multiforme)
07/2019
1Brain Neoplasms (Brain Tumor)
07/2019
1Arthritis (Polyarthritis)
12/2018
1Rheumatoid Arthritis
12/2018
1Synovitis
12/2018
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
11/2018
1Carcinoma (Carcinomatosis)
08/2015
1Colonic Neoplasms (Colon Cancer)
01/2015
1Urinary Bladder Neoplasms (Bladder Cancer)
10/2014
1Mouth Neoplasms (Oral Cancer)
08/2013
1Type 2 Diabetes Mellitus (MODY)
04/2013
1Hepatocellular Carcinoma (Hepatoma)
04/2013

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
12/2021 - 08/2006
5ProdigiosinIBA
12/2012 - 03/2009
3CateninsIBA
12/2021 - 03/2020
3Biological ProductsIBA
12/2021 - 11/2018
3Phosphotransferases (Kinase)IBA
12/2021 - 11/2018
3SurvivinIBA
03/2020 - 03/2009
3Messenger RNA (mRNA)IBA
08/2013 - 05/2008
2Small Interfering RNA (siRNA)IBA
11/2021 - 08/2013
2Annexin A5IBA
11/2020 - 01/2013
2CaspasesIBA
11/2020 - 01/2013
2benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
11/2020 - 01/2013
2obatoclaxIBA
03/2020 - 12/2016
2p38 Mitogen-Activated Protein KinasesIBA
12/2018 - 07/2012
2Pharmaceutical PreparationsIBA
05/2011 - 12/2007
1Heme Oxygenase-1IBA
01/2022
1medicarpinIBA
12/2021
1Brain-Derived Neurotrophic Factor (BDNF)IBA
12/2021
1tyrosine receptor (receptor, tyrosine)IBA
12/2021
1Neuroprotective AgentsIBA
12/2021
1Caspase 3 (Caspase-3)IBA
12/2021
1Air Pollutants (Pollutants, Air)IBA
01/2021
1Ether (Diethyl Ether)IBA
11/2020
1hispolonIBA
11/2020
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
11/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1DesminIBA
08/2019
1CollagenIBA
08/2019
1Carbon Tetrachloride (Tetrachloromethane)IBA
08/2019
1tangeretinIBA
07/2019
1Temozolomide (Temodar)FDA LinkGeneric
07/2019
1ResveratrolIBA
12/2018
1InterleukinsIBA
12/2018
1Collagen Type II (Type II Collagen)IBA
12/2018
1JNK Mitogen-Activated Protein KinasesIBA
12/2018
111-dehydrosinulariolideIBA
11/2018
1Checkpoint Kinase 2IBA
11/2018
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2018
1TensinsIBA
11/2018
1Cyclin D1IBA
12/2016
1Diphenhydramine (Benadryl)FDA LinkGeneric
12/2016
1tanshinoneIBA
08/2015
1Caspase 8 (Caspase-8)IBA
08/2015
1sulforaphaneIBA
01/2015
1Cisplatin (Platino)FDA LinkGeneric
10/2014
1ursaneIBA
10/2014
1TriterpenesIBA
10/2014
1Ursolic AcidIBA
10/2014
1LigandsIBA
10/2013
1Antineoplastic Agents (Antineoplastics)IBA
10/2013
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2013
1DNA (Deoxyribonucleic Acid)IBA
08/2013
1Ligases (Synthetase)IBA
08/2013
1UbiquitinIBA
08/2013
1Metformin (Glucophage)FDA LinkGeneric
04/2013
1dorsomorphinIBA
02/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
02/2013
1AMP-Activated Protein KinasesIBA
02/2013

Therapy/Procedure

7Therapeutics
12/2021 - 03/2004
2Drug Therapy (Chemotherapy)
07/2019 - 10/2013
1Precision Medicine
11/2021
1Radiotherapy
07/2019
1Intraperitoneal Injections
11/2018
1Chemoprevention
10/2013